Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1632
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dc.contributor.authorCardinali, Daniel Pedroes
dc.contributor.authorPagano, Eleonora S.es
dc.contributor.authorScacchi Bernasconi, Pablo A.es
dc.contributor.authorReynoso, Roxanaes
dc.contributor.authorScacchi, Pabloes
dc.date.accessioned2019-05-02T14:01:12Z-
dc.date.available2019-05-02T14:01:12Z-
dc.date.issued2012-
dc.identifier.citationCardinali D. P., et al. Melatonin and mitochondrial dysfunction in the central nervous system [en línea]. Hormones and Behavior. 2013, 63 (2). doi:10.1016/j.yhbeh.2012.02.020. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1632es
dc.identifier.issn0018-506X-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/1632-
dc.description.abstractAbstract: Cell death and survival are critical events for neurodegeneration, mitochondria being increasingly seen as important determinants of both. Mitochondrial dysfunction is considered a major causative factor in Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). Increased free radical generation, enhanced mitochondrial inducible nitric oxide (NO) synthase activity and NO production, and disrupted electron transport system and mitochondrial permeability transition, have all been involved in impaired mitochondrial function. Melatonin, the major secretory product of the pineal gland, is an antioxidant and an effective protector of mitochondrial bioenergetic function. Both in vitro and in vivo, melatonin was effective to prevent oxidative stress/nitrosative stress-induced mitochondrial dysfunction seen in experimental models of AD, PD and HD. These effects are seen at doses 2-3 orders of magnitude higher than those required to affect sleep and circadian rhythms, both conspicuous targets of melatonin action. Melatonin is selectively taken up by mitochondria, a function not shared by other antioxidants. A limited number of clinical studies indicate that melatonin can improve sleep and circadian rhythm disruption in PD and AD patients. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects which were employed in clinical trials in sleep-disturbed or depressed patients in doses considerably higher than those employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin in the range of 50-100 mg/day are needed to assess its therapeutic validity in neurodegenerative disorders.es
dc.formatapplication/pdfes
dc.languageenges
dc.language.isoenges
dc.publisherElsevieres
dc.rightsAcceso Abiertoes
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/es
dc.sourceHormones and Behavior. 2013, 63 (2)es
dc.subjectMELATONINAes
dc.subjectMITOCONDRIASes
dc.subjectSISTEMA NERVIOSO CENTRALes
dc.subjectRADICALES LIBRESes
dc.subjectENVEJECIMIENTOes
dc.subjectSTRESSes
dc.subjectENFERMEDAD DE ALZHEIMERes
dc.subjectENFERMEDAD DE HUNTINGTONes
dc.subjectENFERMEDAD DE PARKINSONes
dc.titleMelatonin and mitochondrial dysfunction in the central nervous systemes
dc.typeArtículoes
dc.identifier.doi10.1016/j.yhbeh.2012.02.020-
uca.pathFacultad de Ciencias Médicas|Departamento de Docencia e Investigaciónes
uca.disciplinaMEDICINAes
uca.filename/home/data-uca-generic/folder_generic/IIBiomedicas/melatonin-mitochondrial-dysfunction-central-nervous/metadata.xmles
uca.issnrd1es
uca.affiliationFil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentinaes
uca.affiliationFil: Pagano, Eleonora S. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentinaes
uca.affiliationFil: Scacchi Bernasconi, Pablo A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentinaes
uca.affiliationFil: Reynoso, Roxana. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentinaes
uca.affiliationFil: Scacchi, Pablo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentinaes
uca.versionsubmittedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Psiconeuroendocrinoinmunología-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.orcid0000-0002-0813-9088-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
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