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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Jiménez Ortega, Vanesa | es |
dc.contributor.author | Cano Barquilla, Pilar | es |
dc.contributor.author | Cardinali, Daniel Pedro | es |
dc.contributor.author | Esquifino, Ana I. | es |
dc.date.accessioned | 2019-05-02T14:01:10Z | - |
dc.date.available | 2019-05-02T14:01:10Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Jiménez-Ortega, V., et al. 24-hour rhythm in gene expression of redox pathway enzymes in rat hypothalamus : effect of melatonin treatment [en línea]. Redox Report 2009, 14 (3). doi:10.1179/135100009X392548. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1626 | es |
dc.identifier.issn | 1351-0002 (impreso) | - |
dc.identifier.issn | 1743-2928 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/1626 | - |
dc.description.abstract | Abstract: The 24-h changes in medial basal hypothalamic (MBH) gene expression of redox pathway enzymes nitric oxide synthase (NOS)-1 and NOS-2, heme oxygenase (HO)-1 and HO-2, Cu/Znand Mn-superoxide dismutases (SOD) and catalase were examined in adult male Wistar rats. Half of the animals received melatonin (ca. 60 μg/day) in the drinking water. After 1 month, rats were killed at six different time intervals, throughout a 24-h cycle. MBH mRNA levels were measured by real-time PCR analysis. In controls NOS-1 mRNA expression did not exhibit 24-h variations while NOS-2 gene expression peaked at the early light phase of cycle. MBH mRNA for both the inducible (HO-1) and constitutive (HO-2) isoforms of HO showed a significant 24 h pattern with a maximum at the middle of the dark phase or at the early light phase, respectively. None of mRNAs encoding Cu/Zn-SOD, Mn-SOD and catalase exhibited significant 24-h variations in rat MBH under control conditions. Chronic melatonin administration in the drinking water decreased significantly mRNAs for NOS-1, NOS-2, HO-1 and HO-2 as well as changed their 24-h profile. Melatonin augmented gene expression of the antioxidant enzymes Cu/Zn-SOD, Mn-SOD or catalase at certain time intervals only | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.language.iso | eng | es |
dc.publisher | Taylor & Francis | es |
dc.rights | Acceso Abierto | es |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | es |
dc.source | Redox Report. 2009, 14 (3) | es |
dc.subject | MELATONINA | es |
dc.subject | RITMO CIRCADIANO | es |
dc.subject | HIPOTALAMO MEDIO | es |
dc.subject | EXPRESION DE GENES | es |
dc.subject | CATALASA | es |
dc.subject | OXIDO NITRICO SINTASA | es |
dc.title | 24-hour rhythm in gene expression of redox pathway enzymes in rat hypothalamus : effect of melatonin treatment | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1179/135100009X392548 | - |
uca.path | Facultad de Ciencias Médicas|Departamento de Docencia e Investigación | es |
uca.disciplina | MEDICINA | es |
uca.filename | /home/data-uca-generic/folder_generic/IIBiomedicas/24-hour-rhythm-gene-expression/metadata.xml | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Jiménez Ortega, Vanesa. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Cano Barquilla, Pilar. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.affiliation | Fil: Cardinali, Daniel P. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentina | es |
uca.affiliation | Fil: Esquifino, Ana I. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; España | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0813-9088 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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