Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1620
DC FieldValueLanguage
dc.contributor.authorPandi Perumal, Seithikurippu R.es
dc.contributor.authorBaHammam, Ahmed S.es
dc.contributor.authorSpence, David Warrenes
dc.contributor.authorBrown, Gregory M.es
dc.contributor.authorBharti, Vijay K.es
dc.contributor.authorKaur, Charanjites
dc.contributor.authorHardeland, Rüdigeres
dc.contributor.authorCardinali, Daniel Pedroes
dc.date.accessioned2019-05-02T14:01:09Z-
dc.date.available2019-05-02T14:01:09Z-
dc.date.issued2012-
dc.identifier.citationPandi-Perumal, S. R., et al. Melatonin antioxidative defense : therapeutical implications for aging and neurodegenerative processes [en línea]. Preprint del documento publicado en Neurotoxicity Research. 2012, 23. doi: 10.1007/s12640-012-9337-4. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1620es
dc.identifier.issn1029-8428 (impreso)-
dc.identifier.issn1476-3524 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/1620-
dc.description.abstractAbstract: The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms, sleep homeostasis, retinal neuromodulation and vasomotor responses. It scavenges hydroxyl, carbonate and various organic radicals as well as a number of reactive nitrogen species. Melatonin also enhances the antioxidant potential of the cell by stimulating the synthesis of antioxidant enzymes including superoxide dismutase, glutathione peroxidase and glutathione reductase, and by augmenting glutathione levels. Melatonin preserves mitochondrial homeostasis, reduces free radical generation and protects mitochondrial ATP synthesis by stimulating Complex I and IV activities. The decline in melatonin production in aged individuals has been suggested as one of the primary contributing factors for the development of age-associated neurodegenerative diseases. The efficacy of melatonin in preventing oxidative damage in either cultured neuronal cells or in the brains of animals treated with various neurotoxic agents, suggests that melatonin has a potential therapeutic value as a neuroprotective drug in treatment of Alzheimer´s disease (AD), Parkinson´s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington´s disease (HD), stroke and brain trauma. Therapeutic trials with melatonin indicate that it has a potential therapeutic value as a neuroprotective drug in treatment of AD, ALS and HD. In the case of other neurological conditions, like PD, the evidence is less compelling. Melatonin’s efficacy in combating free radical damage in the brain suggests that it can be a valuable therapeutic agent in the treatment of cerebral edema following traumatic brain injury or stroke. Clinical trials employing melatonin doses in the range of 50–100 mg/day are warranted before its relative merits as a neuroprotective agent is definitively established.es
dc.formatapplication/pdfes
dc.languageenges
dc.language.isoenges
dc.publisherSpringeres
dc.rightsAcceso Abiertoes
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/es
dc.sourceNeurotoxicity Research. 2013, 23es
dc.subjectMELATONINAes
dc.subjectRADICALES LIBRESes
dc.subjectSTRESSes
dc.subjectENVEJECIMIENTOes
dc.subjectENFERMEDAD DE PARKINSONes
dc.subjectENFERMEDAD DE ALZHEIMERes
dc.subjectENFERMEDAD DE HUNTINGTONes
dc.titleMelatonin antioxidative defense : therapeutical implications for aging and neurodegenerative processeses
dc.typeArtículoes
dc.identifier.doi10.1007/s12640-012-9337-4-
uca.pathFacultad de Ciencias Médicas|Departamento de Docencia e Investigaciónes
uca.disciplinaMEDICINAes
uca.filename/home/data-uca-generic/folder_generic/IIBiomedicas/melatonin-antioxidative-defense-therapeutical-implications/metadata.xmles
uca.issnrd1es
uca.affiliationFil: Pandi Perumal, Seithikurippu R. Somnogen Canada Inc; Canadáes
uca.affiliationFil: Pandi Perumal, Seithikurippu R. King Saud University. Facultad de Medicina. Centro de Desórdenes del Sueño; Arabia Sauditaes
uca.affiliationFil: BaHammam, Ahmed S.King Saud University. Facultad de Medicina. Centro de Desórdenes del Sueño; Arabia Sauditaes
uca.affiliationFil: Spence, David Warren. Investigador Independiente; Canadáes
uca.affiliationFil: Brown, Gregory M. Universidad de Toronto. Departamento de Psiquiatría; Canadáes
uca.affiliationFil: Brown, Gregory M. Centre for Addiction and Mental Health; Canadáes
uca.affiliationFil: Bharti, Vijay K. Ministry of Defence. Defence Research and Development Organization. Defence Institute of High Altitude Research; Nutrition and Toxicology Laboratory; Indiaes
uca.affiliationFil: Kaur, Charanjit. National University of Singapore. Yong Loo Lin School of Medicine. Department of Anatomy; Singapures
uca.affiliationFil: Hardeland, Rüdiger. Universidad de Goettingen. Insituto Johann Friedrich Blumenbach de Zoología y Antropología; Alemaniaes
uca.affiliationFil: Cardinali, Daniel P. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentinaes
uca.versionpublishedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.orcid0000-0002-0813-9088-
crisitem.author.parentorgFacultad de Ciencias Médicas-
Appears in Collections:Artículos
Files in This Item:
File Description SizeFormat
melatonin-antioxidative-defense-therapeutical-implications.pdf821,64 kBAdobe PDFThumbnail
View/Open
Show simple item record

Page view(s)

172
checked on May 13, 2021

Download(s)

329
checked on May 13, 2021

Google ScholarTM

Check


Altmetric


This item is licensed under a Creative Commons License Creative Commons