Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/1619
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dc.contributor.authorCardinali, Daniel Pedroes
dc.contributor.authorCano Barquilla, Pilares
dc.contributor.authorJiménez Ortega, Vanesaes
dc.contributor.authorEsquifino, Ana I.es
dc.date.accessioned2019-05-02T14:01:08Z-
dc.date.available2019-05-02T14:01:08Z-
dc.date.issued2011-
dc.identifier.citationCardinali, D. P., et al. Melatonin and the metabolic syndrome : physiopathologic and therapeutical implications [en línea]. Preprint de artículo publicado en Neuroendocrinology. 2011, 93 (3). doi:10.1159/000324699. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1619es
dc.identifier.issn0028-3835 (Print)-
dc.identifier.issn1423-0194 (Online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/1619-
dc.description.abstractAbstract: Metabolic syndrome (MS) patients exhibit sleep/wake disturbances and other circadian abnormalities and these may be associated with more rapid weight increase and development of diabetes and atherosclerotic disease. On this basis, the successful management of MS may require an ideal drug that besides antagonizing the trigger factors of MS could also correct the disturbed sleep‐wake rhythm. Melatonin is an effective chronobiotic agent able to change the phase and amplitude of circadian rhythms. Melatonin has also significant cytoprotective properties preventing a number of MS sequela in animal models of diabetes and obesity. A small number of controlled trials indicate that melatonin is useful to treat the metabolic and cardiovascular comorbilities of MS. Whether the recently introduced melatonergic agents (ramelteon, agomelatine, tasimelteon) have the potential for treating sleep disorders in MS patients and, more generally, for arresting the progression of disease merits further investigation.es
dc.formatapplication/pdfes
dc.languageenges
dc.language.isoenges
dc.publisherKarger Publisherses
dc.rightsAcceso Abiertoes
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/es
dc.sourceNeuroendocrinology 2011, 93 (3)es
dc.subjectMELATONINAes
dc.subjectRITMO CIRCADIANOes
dc.subjectSINDROME METABOLICOes
dc.subjectAGONISTASes
dc.titleMelatonin and the metabolic syndrome : physiopathologic and therapeutical implicationses
dc.typeArtículoes
dc.identifier.doi10.1159/000324699-
uca.pathFacultad de Ciencias Médicas|Departamento de Docencia e Investigaciónes
uca.disciplinaMEDICINAes
uca.filename/home/data-uca-generic/folder_generic/IIBiomedicas/melatonin-metabolic-syndrome-physiopathologic/metadata.xmles
uca.issnrd1es
uca.affiliationFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentinaes
uca.affiliationFil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Fisiología; Argentinaes
uca.affiliationFil: Cano Barquilla, Pilar. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; Españaes
uca.affiliationFil: Jiménez Ortega, Vanesa. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; Españaes
uca.affiliationFil: Esquifino, Ana I. Universidad Complutense. Facultad de Medicina. Departamento de Bioquímica y Biología Molecular III; Españaes
uca.versionsubmittedVersiones
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.orcid0000-0002-0813-9088-
crisitem.author.parentorgFacultad de Ciencias Médicas-
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