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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Srinivasan, Venkataramanujan | es |
dc.contributor.author | Pandi Perumal, Seithikurippu R. | es |
dc.contributor.author | Cardinali, Daniel Pedro | es |
dc.contributor.author | Spence, David Warren | es |
dc.contributor.author | Kato, Hisanori | es |
dc.date.accessioned | 2019-05-02T14:01:05Z | - |
dc.date.available | 2019-05-02T14:01:05Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Srinivasan, V., et al. Melatonin in septic shock : some recent concepts. Preprint de artículo publicado en Journal of Critical Care. 2010, 25. doi:10.1016/j.jcrc.2010.03.006. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1611 | es |
dc.identifier.issn | 0883-9441 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/1611 | - |
dc.description.abstract | Abstract: Melatonin is a versatile molecule, synthesized not only in the pineal gland, but also in many other organs. Melatonin plays an important physiological role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control and regulation of mood. Melatonin has also been reported as effective in combating various bacterial and viral infections. Melatonin is an effective anti-inflammatory agent in various animal models of inflammation and sepsis and its anti-inflammatory action has been attributed to inhibition of nitric oxide synthase with consequent reduction of peroxynitrite formation, to the stimulation of various antioxidant enzymes thus contributing to enhance the antioxidant defense and to protective effects on mitochondrial function and in preventing apoptosis. In a number of animal models of septic shock, as well as in patients with septic disease, melatonin reportedly exerts beneficial effects to arrest cellular damage and multiorgan failure. The significance of these actions in septic shock and its potential usefulness in the treatment of multiorgan failure are discussed. | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Acceso Abierto | es |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | es |
dc.source | Journal of Critical Care. 2010, 25 | es |
dc.subject | MELATONINA | es |
dc.subject | ANTIOXIDANTES | es |
dc.subject | OXIDO NITRICO | es |
dc.subject | CITOCINAS | es |
dc.subject | CHOQUE SEPTICO | es |
dc.title | Melatonin in septic shock : some recent concepts | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.jcrc.2010.03.006 | - |
uca.path | Facultad de Ciencias Médicas|Departamento de Docencia e Investigación | es |
uca.disciplina | MEDICINA | es |
uca.filename | /home/data-uca-generic/folder_generic/IIBiomedicas/melatonin-septic-shock-recent-concepts/metadata.xml | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Srinivasan, Venkataramanujan. Sri Sathya Sai Medical Educational and Research Foundation; India | es |
uca.affiliation | Fil: Pandi Perumal, Seithikurippu R. Somnogen Inc; Estados Unidos | es |
uca.affiliation | Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Medicina. Departamento de Docencia e Investigación; Argentina | es |
uca.affiliation | Fil: Spence, David Warren. Investigador Independiente; Canadá | es |
uca.affiliation | Fil: Kato, Hisanori. The University of Tokyo. Graduate School of Agricultural and Life Sciences. Department of Applied Biological Chemistry; Japón | es |
uca.version | submittedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0813-9088 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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