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https://repositorio.uca.edu.ar/handle/123456789/15358
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Numaga-Tomita, Takuro | es |
dc.contributor.author | Shimauchi, Tsukasa | es |
dc.contributor.author | Kato, Yuri | es |
dc.contributor.author | Nishiyama, Kazuhiro | es |
dc.contributor.author | Nishimura, Akiyuki | es |
dc.contributor.author | Sakata, Kosuke | es |
dc.contributor.author | Inada, Hiroyuki | es |
dc.contributor.author | Kita, Satomi | es |
dc.contributor.author | Iwamoto, Takahiro | es |
dc.contributor.author | Nabekura, Junichi | es |
dc.contributor.author | Birnbaumer, Lutz | es |
dc.contributor.author | Mori, Yasuo | es |
dc.contributor.author | Nishida, Motohiro | es |
dc.date.accessioned | 2022-10-28T20:47:10Z | - |
dc.date.available | 2022-10-28T20:47:10Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Numaga-Tomita, T. et al. Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery [en línea]. British Journal of Pharmacology, 2022. doi: 10.1111/bph.15942. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15358 | es |
dc.identifier.issn | 0007-1188 (impreso) | - |
dc.identifier.issn | 1476-5381 (on line) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/15358 | - |
dc.description.abstract | Abstract: Background and Purpose: Capillary arterialization, characterized by the coverage of pre-existing or nascent capillary vessels with vascular smooth muscle cells (VSMCs), is critical for the development of collateral arterioles to improve post-ischaemic blood flow. We previously demonstrated that the inhibition of transient receptor potential 6 subfamily C, member 6 (TRPC6) channels facilitate contractile differentiation of VSMCs under ischaemic stress. We here investigated whether TRPC6 inhibition promotes post-ischaemic blood flow recovery through capillary arterialization in vivo. Experimental Approach: Mice were subjected to hindlimb ischaemia by ligating left femoral artery. The recovery rate of peripheral blood flow was calculated by the ratio of ischaemic left leg to non-ischaemic right one. The number and diameter of blood vessels were analysed by immunohistochemistry. Expression and phosphorylation levels of TRPC6 proteins were determined by western blotting and immunohistochemistry. Key Results: Although the post-ischaemic blood flow recovery is reportedly dependent on endothelium-dependent relaxing factors, systemic TRPC6 deletion significantly promoted blood flow recovery under the condition that nitric oxide or prostacyclin production were inhibited, accompanying capillary arterialization. Cilostazol, a clinically approved drug for peripheral arterial disease, facilitates blood flow recovery by inactivating TRPC6 via phosphorylation at Thr69 in VSMCs. Furthermore, inhibition of TRPC6 channel activity by pyrazole-2 (Pyr2; BTP2; YM-58483) promoted post-ischaemic blood flow recovery in Apolipoprotein E-knockout mice. Conclusion and Implications: Suppression of TRPC6 channel activity in VSMCs could be a new strategy for the improvement of post-ischaemic peripheral blood circulation. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | British Journal of Pharmacology, 2022 | es |
dc.subject | TRPC6 | es |
dc.subject | ENFERMEDAD ATEROSCLEROTICA | es |
dc.subject | RECEPTORES | es |
dc.subject | CÉLULA MUSCULAR LISA VASCULAR | es |
dc.subject | FOSFORILACIÓN | es |
dc.title | Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1111/bph.15942 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Numaga-Tomita, Takuro. National Institutes of Natural Sciences. National Institute for Physiological Sciences; Japón | es |
uca.affiliation | Fil: Numaga-Tomita, Takuro. National Institutes of Natural Sciences. Exploratory Research Center on Life and Living Systems; Japón | es |
uca.affiliation | Fil: Numaga-Tomita, Takuro. The Graduate University for Advanced Studies. School of Life Science. SOKENDAI; Japón | es |
uca.affiliation | Fil: Numaga-Tomita, Takuro. Shinshu University School of Medicine; Japón | es |
uca.affiliation | Fil: Shimauchi, Tsukasa. National Institutes of Natural Sciences. National Institute for Physiological Sciences; Japón | es |
uca.affiliation | Fil: Shimauchi, Tsukasa. National Institutes of Natural Sciences. Exploratory Research Center on Life and Living Systems; Japón | es |
uca.affiliation | Fil: Shimauchi, Tsukasa. Kyushu University. Graduate School of Pharmaceutical Sciences; Japón | es |
uca.affiliation | Fil: Shimauchi, Tsukasa. Kyushu University. Graduate School of Medical Sciences; Japón | es |
uca.affiliation | Fil: Kato, Yuri. Kyushu University. Graduate School of Pharmaceutical Sciences; Japón | es |
uca.affiliation | Fil: Nishiyama, Kazuhiro. Kyushu University. Graduate School of Pharmaceutical Sciences; Japón | es |
uca.affiliation | Fil: Nishimura, Akiyuki. National Institutes of Natural Sciences. National Institute for Physiological Sciences; Japón | es |
uca.affiliation | Fil: Nishimura, Akiyuki. National Institutes of Natural Sciences. Exploratory Research Center on Life and Living Systems; Japón | es |
uca.affiliation | Fil: Nishimura, Akiyuki. The Graduate University for Advanced Studies. School of Life Science. SOKENDAI; Japón | es |
uca.affiliation | Fil: Sakata, Kosuke. Kyushu University. Graduate School of Pharmaceutical Sciences; Japón | es |
uca.affiliation | Fil: Inada, Hiroyuki. National Institutes of Natural Sciences. National Institute for Physiological Sciences; Japón | es |
uca.affiliation | Fil: Kita, Satomi. Fukuoka University. Faculty of Medicine; Japón | es |
uca.affiliation | Fil: Kita, Satomi. Tokushima Bunri University. Faculty of Pharmaceutical Sciences; Japón | es |
uca.affiliation | Fil: Iwamoto, Takahiro. Fukuoka University. Faculty of Medicine; Japón | es |
uca.affiliation | Fil: Nabekura, Junichi. National Institutes of Natural Sciences. National Institute for Physiological Sciences; Japón | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Research Triangle Park. National Institutes of Health. National Institute of Environmental Health Sciences; Estados Unidos | es |
uca.affiliation | Fil: Birnbaumer, Lutz. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Mori, Yasuo. Kyoto University. Graduate School of Engineering; Japón | es |
uca.affiliation | Fil: Nishida, Motohiro. National Institutes of Natural Sciences. National Institute for Physiological Sciences; Japón | es |
uca.affiliation | Fil: Nishida, Motohiro. National Institutes of Natural Sciences. Exploratory Research Center on Life and Living Systems; Japón | es |
uca.affiliation | Fil: Nishida, Motohiro. The Graduate University for Advanced Studies. School of Life Science. SOKENDAI; Japón | es |
uca.affiliation | Fil: Nishida, Motohiro. Kyushu University. Graduate School of Pharmaceutical Sciences; Japón | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Función y Farmacología de Canales Iónicos | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-0775-8661 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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