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https://repositorio.uca.edu.ar/handle/123456789/15249
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Tesan, Fiorella Carla | es |
dc.contributor.author | Portillo, Mariano Gaston | es |
dc.contributor.author | Martinel Lamas, Diego José | es |
dc.contributor.author | Medina, Vanina Araceli | es |
dc.contributor.author | Salgueiro, Maria Jimena | es |
dc.contributor.author | Zubillaga, Marcela Beatriz | es |
dc.date.accessioned | 2022-10-19T12:50:21Z | - |
dc.date.available | 2022-10-19T12:50:21Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Tesan, F.C., et al. Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging [en línea]. Anti-Cancer Agents in Medicinal Chemistry. 2017, 17(3) doi:10.2174/1871520616666151110130619 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15249 | es |
dc.identifier.issn | 1871-5206 | - |
dc.identifier.issn | 1875-5992 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/15249 | - |
dc.description.abstract | Abstract: Background: Chemotherapy is one of the most common approaches for cancer treatment. Particularly Doxorubicin has been proven to be effective in the treatment of many soft and solid tumors for locally advanced and metastatic cancer. It is not easy to clinically evaluate the chemotoxic or chemoprotective effect of some drugs, even more when there is a subclinical toxicity. Objective: To determine the usefulness of the hepatobiliary, colloid and cardiac scintigraphies, employing 99mTcdisida, 99mTc-phytate and 99mTc-sestamibi respectively, in the evaluation of the hepato and cardiotoxicity of two chemotherapeutic treatments assessed in rats. Method: Two groups were submitted to doxorubicin (DOX) treatment and one was co-administered with histamine (DOX+HIS). Static 99mTc-phytate and 99mTc-sestamibi scintigraphies as well as a dynamic 99mTc-disida study were performed in a small field of view gamma camera at: 0 weeks (control), 1 week and 2 weeks of treatment. Imagenological parameters were calculated: Liver/Bone Marrow ratio (L/BM), Heart/Background ratio (H/B) and time to the maximum (Tmax) for 99mTc-phytate, 99mTc-sestamibi and 99mTc-disida extraction, respectively. Results: Control (L/BM= 98±3; H/B=2.3±0.4; Tmax=8±3), DOX (L/BM: 85±3, 80±3; H/B, 3.5±0.5, 3.3±0.5 and Tmax 6±1, 4±1) for 1 and 2 weeks respectively and DOX+HIS (L/BM: 99±0.3, 98±1; H/B 2.9±0.5, 2.9±0.5 and Tmax, 8±2, 9±2) for 1 and 2 weeks, respectively. Histological analysis showed cardio and hepatotoxicity induced by doxorubicin. Conclusion: Imagenological parameters showed differences among treated and control groups and between both chemotherapy treatments. Thus, these radiopharmaceutical functional approaches were able to reflect heart and liver toxicity produced by doxorubicin. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Bentham Science | es |
dc.rights | info:eu-repo/semantics/closedAccess | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Anti-Cancer Agents in Medicinal Chemistry. 2017, 17(3) | es |
dc.subject | HISTAMINA | es |
dc.subject | ESTRUCTURA MOLECULAR | es |
dc.subject | DOXORRUBICINA | es |
dc.subject | HIGADO | es |
dc.subject | CORAZON | es |
dc.title | Hepato and cardiotoxicity of chemotherapeutic treatment evaluated by means of small animal imaging | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.2174/1871520616666151110130619 | - |
dc.identifier.pmid | 26552391 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina | es |
uca.affiliation | Fil: Portillo, Mariano Gaston. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina | es |
uca.affiliation | Fil: Martinel Lamas, Diego José. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina | es |
uca.affiliation | Fil: Martinel Lamas, Diego José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Martinel Lamas, Diego José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina | es |
uca.affiliation | Fil: Medina, Vanina Araceli. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina | es |
uca.affiliation | Fil: Medina, Vanina Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina | es |
uca.affiliation | Fil: Salgueiro, Maria Jimena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina | es |
uca.affiliation | Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisotopos; Argentina | es |
uca.affiliation | Fil: Zubillaga, Marcela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Laboratorio de Biología Tumoral e Inflamación | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Biología Tumoral e Inflamación | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-7767-0729 | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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