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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Baier, Carlos J. | es |
dc.contributor.author | Fantini, Jacques | es |
dc.contributor.author | Barrantes, Francisco José | es |
dc.date.accessioned | 2019-05-02T13:56:20Z | - |
dc.date.available | 2019-05-02T13:56:20Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Baier, C. J., Fantini, J., Barrantes, F. J. Disclosure of cholsterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor [en línea]. Scientific Reports. 2011. 1 (69). doi:10.1038/srep00069. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1462 | es |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/1462 | - |
dc.description.abstract | Abstract: Cholesterol influences ion-channel function, distribution and clustering in the membrane, endocytosis, and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report the occurrence of a cholesterol recognition motif, here coined ‘‘CARC’’, in the transmembrane regions of AChR subunits that bear extensive contact with the surrounding lipid, and are thus optimally suited to convey cholesterol-mediated signaling from the latter. Three cholesterol molecules could be docked on the transmembrane segments of each AChR subunit, rendering a total of 15 cholesterol molecules per AChR molecule. The CARC motifs contribute each with an energy of interaction between 35 and 52 kJ.mol21, adding up to a total of about 200 kJ.mol21 per receptor molecule, i.e. 40% of the lipid solvation free energy/ AChR molecule. The CARC motif is remarkably conserved along the phylogenetic scale, from prokaryotes to human, suggesting that it could be responsible for some of the above structural/functional properties of the AChR. | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.language.iso | spa | es |
dc.publisher | Nature Research | es |
dc.rights | Acceso Abierto | es |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | es |
dc.source | Scientific Reports. 2011, 1 (69) | es |
dc.subject | COLESTEROL | es |
dc.subject | LIPIDOS | es |
dc.subject | CANALES IONICOS | es |
dc.subject | NEUROCIENCIA | es |
dc.subject | ACHR | es |
dc.subject | NEUROBIOLOGIA MOLECULAR | es |
dc.title | Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1038/srep00069 | - |
dc.identifier.pmid | 22355588 | - |
uca.path | Facultad de Ciencias Médicas|Instituto de Investigaciones Biomédicas (BIOMED UCA-CONICET) | es |
uca.disciplina | MEDICINA | es |
uca.filename | /home/data-uca-generic/folder_generic/IIBiomedicas/disclosure-cholesterol-recognition-motifs/metadata.xml | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Baier, Carlos J. Universidad de Buenos Aires, Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas; Argentina | es |
uca.affiliation | Fil: Baier, Carlos J. Pontificia Universidad Católica Argentina. Programa de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina | es |
uca.affiliation | Fil: Baier, Carlos J. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Fantini, Jacques. Université Paul Cézanne; Francia | es |
uca.affiliation | Fil: Fantini, Jacques. Université de la Méditerrané, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille; Francia | es |
uca.affiliation | Fil: Barrantes, Francisco J. Universidad de Buenos Aires, Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Fisicoquímica Biológicas; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco J. Instituto de Investigaciones Bioquímicas de Bahíaa Blanca; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco J. United Nations Educational, Scientific and Cultural Organization. Chair of Biophysics and Molecular Neurobiology; Francia | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | es | - |
item.grantfulltext | open | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-4745-681X | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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