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https://repositorio.uca.edu.ar/handle/123456789/14562
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Massip Copiz, María Macarena | es |
dc.contributor.author | Santa Coloma, Tomás Antonio | es |
dc.date.accessioned | 2022-07-26T13:18:02Z | - |
dc.date.available | 2022-07-26T13:18:02Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Massip Copiz, M. M., Santa Coloma, T. A. c- Src and its role in cystic fibrosis [en línea]. European Journal of Cell Biology. 2016, 95 (10). doi: https://doi.org/10.1016/j.ejcb.2016.08.001. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14562 | es |
dc.identifier.issn | 0070-2463 (online) | - |
dc.identifier.issn | 0171-9335 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/14562 | - |
dc.description.abstract | Abstract: Cystic fibrosis (CF) is a lethal inherited disease produced by mutations in the gene encoding the CFTR chloride channel. Loss of function in the CFTR gene is associated with a not much noticed increased expression and activity of the non-receptor protein-tyrosine kinase c-Src. CF is therefore the result from the loss of CFTR chloride transport function and its consequences, including a chronic and excessive c-Src signaling. On the other hand, c-Src, encoded by the SRC gene, is involved in diverse signaling mechanisms that regulate key cellular functions such as cell proliferation, apoptosis, oxidative stress, inflammation, and innate immunity. These c-Src-regulated cellular functions are also affected in CF; however, studies exploring a direct role of c-Src in the regulation of these cellular functions in CF are yet scarce and often controversial. Here we describe the c-Src regulation and functions, with emphasis in those altered in CF, and describe the role of CFTR as a “signaling molecule” that negatively modulates c-Src expression and activity. It is also discussed the emerging role of intracellular Cl− and IL-1 as intermediate signaling effectors between CFTR and c-Src. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | European Journal of Cell Biology Vol.95, No.10, 2016 | es |
dc.subject | FIBROSIS QUISTICA | es |
dc.subject | GENES | es |
dc.subject | CLORURO INTRACELULAR | es |
dc.subject | REGULADOR DE CONDUCTANCIA DE TRANSMEMBRANA DE FIBROSIS QUISTICA | es |
dc.title | c- Src and its role in cystic fibrosis | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.ejcb.2016.08.001 | - |
dc.identifier.pmid | 27530912 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 0 | es |
uca.affiliation | Fil: Massip Copiz, María Macarena. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina | es |
uca.affiliation | Fil: Massip Copiz, María Macarena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Santa Coloma, Tomás Antonio. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Celular y Molecular; Argentina | es |
uca.affiliation | Fil: Santa Coloma, Tomás Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.version | publishedVersion | es |
item.grantfulltext | embargo_21000101 | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Biología Celular y Molecular | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Biología Celular y Molecular | - |
crisitem.author.dept | Laboratorio de Nanotecnología | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-3266-1095 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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