Por favor, use este identificador para citar o enlazar este ítem: https://repositorio.uca.edu.ar/handle/123456789/14304
Campo DC Valor Lengua/Idioma
dc.contributor.authorPérez Lloret, Santiagoes
dc.contributor.authorPeralta, María Ceciliaes
dc.contributor.authorBarrantes, Francisco Josées
dc.date.accessioned2022-06-29T12:16:36Z-
dc.date.available2022-06-29T12:16:36Z-
dc.date.issued2016-
dc.identifier.citationPérez Lloret, S., Peralta, M.C., Barrantes, F.J. Pharmacotherapies for parkinson's disease symptoms related to cholinergic degeneration [en línea]. Expert Opinion on Pharmacotherapy. 2016, 17(18) doi:10.1080/14656566.2016.1254189 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14304es
dc.identifier.issn1465-6566-
dc.identifier.issn1744-7666 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/14304-
dc.description.abstractAbstract: Dopamine depletion is one of the most important features of Parkinson's Disease (PD). However, insufficient response to dopaminergic replacement therapy suggests the involvement of other neurotransmitter systems in the pathophysiology of PD. Cholinergic degeneration contributes to gait impairments, cognitive impairment, psychosis, and REM-sleep disturbances, among other symptoms. Areas covered: In this review, we explore the idea that enhancing cholinergic tone by pharmacological or neurosurgical procedures could be a first-line therapeutic strategy for the treatment of symptoms derived from cholinergic degeneration in PD. Expert opinion: Rivastigmine, a drug that increases cholinergic tone by inhibiting the enzyme cholinesterase, is effective for dementia, whereas the use of Donepezil is still in the realm of investigation. Interesting results suggest the efficacy of these drugs in the treatment of gait dysfunction. Evidence on the clinical effects of these drugs for psychosis and REM-sleep disturbances is still weak. Stimulation of the pedunculo-pontine tegmental nuclei (which provide cholinergic innervation to the brain stem and subcortical nuclei) has also been used with some success for the treatment of gait dysfunction. Anticholinergic drugs should be used with caution in PD, as they may aggravate cholinergic symptoms. Notwithstanding, in some patients they might help control parkinsonian motor symptoms.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherTaylor & Francises
dc.rightsinfo:eu-repo/semantics/closedAccess*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceExpert Opinion on Pharmacotherapy. 2016, 17(18)es
dc.subjectTRATAMIENTO MEDICOes
dc.subjectENFERMEDAD DE PARKINSONes
dc.subjectNEURODEGENERACIONes
dc.subjectDETERIORO COGNITIVOes
dc.subjectDEMENCIAes
dc.titlePharmacotherapies for parkinson's disease symptoms related to cholinergic degenerationes
dc.typeArtículoes
dc.identifier.doi10.1080/14656566.2016.1254189-
dc.identifier.pmid27785919-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Pérez Lloret, Santiago. Universidad de Buenos Aires. Instituto de Investigación Cardiológica; Argentinaes
uca.affiliationFil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentinaes
uca.affiliationFil: Peralta, María Cecilia. Hospital Universitario CEMIC; Argentinaes
uca.affiliationFil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentinaes
uca.affiliationFil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Ténicas; Argentinaes
uca.versionpublishedVersiones
item.grantfulltextmixedopen-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.deptLaboratorio de Neurobiología Molecular-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Neurobiología Molecular-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0001-9069-6512-
crisitem.author.orcid0000-0002-4745-681X-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
Aparece en las colecciones: Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato Usuarios registrados haga click en: Login
pharmacotherapies-for-parkinson.pdf1,08 MBAdobe PDF  
thumb.pdf160,41 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro sencillo del ítem

Visualizaciones de página(s)

84
comprobado en 27-abr-2024

Descarga(s)

21
comprobado en 27-abr-2024

Google ScholarTM

Consultar


Altmetric


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons