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https://repositorio.uca.edu.ar/handle/123456789/14227
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Martial, Charlotte | es |
dc.contributor.author | Cassol, Helena | es |
dc.contributor.author | Charland-Verville, Vanessa | es |
dc.contributor.author | Pallavicini, Carla | es |
dc.contributor.author | Sanz, Camila | es |
dc.contributor.author | Zamberlan, Federico | es |
dc.contributor.author | Martínez Vivot, Rocío | es |
dc.contributor.author | Erowid, Fire | es |
dc.contributor.author | Erowid, Earth | es |
dc.contributor.author | Laureys, Steven | es |
dc.contributor.author | Greyson, Bruce | es |
dc.contributor.author | Tagliazucchi, Enzo | es |
dc.date.accessioned | 2022-06-22T15:19:27Z | - |
dc.date.available | 2022-06-22T15:19:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Martial, C. et al. Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports [en línea]. Consciousness and Cognition. 2019, 69 doi:10.1016/j.concog.2019.01.011 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14227 | es |
dc.identifier.issn | 1090-2376 (online) | - |
dc.identifier.issn | 1053-8100 (impreso) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/14227 | - |
dc.description.abstract | Abstract: The real or perceived proximity to death often results in a non-ordinary state of consciousness characterized by phenomenological features such as the perception of leaving the body boundaries, feelings of peace, bliss and timelessness, life review, the sensation of traveling through a tunnel and an irreversible threshold. Near-death experiences (NDEs) are comparable among individuals of different cultures, suggesting an underlying neurobiological mechanism. Anecdotal accounts of the similarity between NDEs and certain drug-induced altered states of consciousness prompted us to perform a large-scale comparative analysis of these experiences. After assessing the semantic similarity between ≈15,000 reports linked to the use of 165 psychoactive substances and 625 NDE narratives, we determined that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine consistently resulted in reports most similar to those associated with NDEs. Ketamine was followed by Salvia divinorum (a plant containing a potent and selective κ receptor agonist) and a series of serotonergic psychedelics, including the endogenous serotonin 2A receptor agonist N,N-Dimethyltryptamine (DMT). This similarity was driven by semantic concepts related to consciousness of the self and the environment, but also by those associated with the therapeutic, ceremonial and religious aspects of drug use. Our analysis sheds light on the long-standing link between certain drugs and the experience of "dying", suggests that ketamine could be used as a safe and reversible experimental model for NDE phenomenology, and supports the speculation that endogenous NMDA antagonists with neuroprotective properties may be released in the proximity of death. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Consciousness and Cognition. 2019, 69 | es |
dc.subject | MUERTE | es |
dc.subject | FENOMENOLOGIA | es |
dc.subject | SUSTANCIAS PSICOACTIVAS | es |
dc.subject | FARMACOLOGIA | es |
dc.subject | ALUCINOGENOS | es |
dc.subject | CONCIENCIA | es |
dc.title | Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.concog.2019.01.011 | - |
dc.identifier.pmid | 30711788 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Martial, Charlotte. University Hospital of Liège. Consciousness and Neurology Department; Bélgica | es |
uca.affiliation | Fil: Cassol, Helena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Cassol, Helena. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Charland-Verville, Vanessa. University Hospital of Liège. Consciousness and Neurology Department; Bélgica | es |
uca.affiliation | Fil: Pallavicini, Carla. Universidad de Buenos Aires. Departamento de Física; Argentina | es |
uca.affiliation | Fil: Pallavicini, Carla. Fundación para la lucha contra las enfermedades neurológicas de la infancia; Argentina | es |
uca.affiliation | Fil: Martínez Vivot, Rocío. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Martínez Vivot, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Zamberlan, Federico. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Zamberlan, Federico. Universidad de Buenos Aires. Departamento de Física; Argentina | es |
uca.affiliation | Fil: Erowid, Fire. Erowid Center; Estados Unidos | es |
uca.affiliation | Fil: Erowid, Earth. Erowid Center; Estados Unidos | es |
uca.affiliation | Fil: Laureys, Steven. University Hospital of Liège. Consciousness and Neurology Department; Bélgica | es |
uca.affiliation | Fil: Greyson, Bruce. University of Virginia Health System. Department of Psychiatry and Neurobehavioral Sciences; Estados Unidos | es |
uca.affiliation | Fil: Tagliazucchi, Enzo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Tagliazucchi, Enzo. Institut du cerveau et de la moelle épinière; Francia | es |
uca.version | acceptedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Cronofisiología | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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