Please use this identifier to cite or link to this item: https://repositorio.uca.edu.ar/handle/123456789/14227
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dc.contributor.authorMartial, Charlottees
dc.contributor.authorCassol, Helenaes
dc.contributor.authorCharland-Verville, Vanessaes
dc.contributor.authorPallavicini, Carlaes
dc.contributor.authorSanz, Camilaes
dc.contributor.authorZamberlan, Federicoes
dc.contributor.authorMartínez Vivot, Rocíoes
dc.contributor.authorErowid, Firees
dc.contributor.authorErowid, Earthes
dc.contributor.authorLaureys, Stevenes
dc.contributor.authorGreyson, Brucees
dc.contributor.authorTagliazucchi, Enzoes
dc.date.accessioned2022-06-22T15:19:27Z-
dc.date.available2022-06-22T15:19:27Z-
dc.date.issued2019-
dc.identifier.citationMartial, C. et al. Neurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reports [en línea]. Consciousness and Cognition. 2019, 69 doi:10.1016/j.concog.2019.01.011 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14227es
dc.identifier.issn1090-2376 (online)-
dc.identifier.issn1053-8100 (impreso)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/14227-
dc.description.abstractAbstract: The real or perceived proximity to death often results in a non-ordinary state of consciousness characterized by phenomenological features such as the perception of leaving the body boundaries, feelings of peace, bliss and timelessness, life review, the sensation of traveling through a tunnel and an irreversible threshold. Near-death experiences (NDEs) are comparable among individuals of different cultures, suggesting an underlying neurobiological mechanism. Anecdotal accounts of the similarity between NDEs and certain drug-induced altered states of consciousness prompted us to perform a large-scale comparative analysis of these experiences. After assessing the semantic similarity between ≈15,000 reports linked to the use of 165 psychoactive substances and 625 NDE narratives, we determined that the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine consistently resulted in reports most similar to those associated with NDEs. Ketamine was followed by Salvia divinorum (a plant containing a potent and selective κ receptor agonist) and a series of serotonergic psychedelics, including the endogenous serotonin 2A receptor agonist N,N-Dimethyltryptamine (DMT). This similarity was driven by semantic concepts related to consciousness of the self and the environment, but also by those associated with the therapeutic, ceremonial and religious aspects of drug use. Our analysis sheds light on the long-standing link between certain drugs and the experience of "dying", suggests that ketamine could be used as a safe and reversible experimental model for NDE phenomenology, and supports the speculation that endogenous NMDA antagonists with neuroprotective properties may be released in the proximity of death.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rightsAcceso abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceConsciousness and Cognition. 2019, 69es
dc.subjectMUERTEes
dc.subjectFENOMENOLOGIAes
dc.subjectSUSTANCIAS PSICOACTIVASes
dc.subjectFARMACOLOGIAes
dc.subjectALUCINOGENOSes
dc.subjectCONCIENCIAes
dc.titleNeurochemical models of near-death experiences : a large-scale study based on the semantic similarity of written reportses
dc.typeArtículoes
dc.identifier.doi10.1016/j.concog.2019.01.011-
dc.identifier.pmid30711788-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Martial, Charlotte. University Hospital of Liège. Consciousness and Neurology Department; Bélgicaes
uca.affiliationFil: Cassol, Helena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Cassol, Helena. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Charland-Verville, Vanessa. University Hospital of Liège. Consciousness and Neurology Department; Bélgicaes
uca.affiliationFil: Pallavicini, Carla. Universidad de Buenos Aires. Departamento de Física; Argentinaes
uca.affiliationFil: Pallavicini, Carla. Fundación para la lucha contra las enfermedades neurológicas de la infancia; Argentinaes
uca.affiliationFil: Martínez Vivot, Rocío. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Martínez Vivot, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Zamberlan, Federico. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Zamberlan, Federico. Universidad de Buenos Aires. Departamento de Física; Argentinaes
uca.affiliationFil: Erowid, Fire. Erowid Center; Estados Unidoses
uca.affiliationFil: Erowid, Earth. Erowid Center; Estados Unidoses
uca.affiliationFil: Laureys, Steven. University Hospital of Liège. Consciousness and Neurology Department; Bélgicaes
uca.affiliationFil: Greyson, Bruce. University of Virginia Health System. Department of Psychiatry and Neurobehavioral Sciences; Estados Unidoses
uca.affiliationFil: Tagliazucchi, Enzo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Tagliazucchi, Enzo. Institut du cerveau et de la moelle épinière; Franciaes
uca.versionacceptedVersiones
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Cronofisiología-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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