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dc.contributor.authorZamberlan, Federicoes
dc.contributor.authorSanz, Camilaes
dc.contributor.authorMartínez Vivot, Rocíoes
dc.contributor.authorPallavicini, Carlaes
dc.contributor.authorErowid, Firees
dc.contributor.authorErowid, Earthes
dc.contributor.authorTagliazucchi, Enzoes
dc.date.accessioned2022-06-22T13:22:22Z-
dc.date.available2022-06-22T13:22:22Z-
dc.date.issued2018-
dc.identifier.citationZamberlan, F. et al. The varieties of the psychedelic experience : a preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [en línea]. Frontiers in Integrative Neuroscience. 2012, 12:54 doi:10.3389/fnint.2018.00054 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14226es
dc.identifier.issn1662-5145-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/14226-
dc.description.abstractAbstract: Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of the user ("set") and the surroundings ("setting"). The observation of cross-tolerance and a series of empirical studies in humans and animal models support agonism at the serotonin (5-HT)2A receptor as a common mechanism for the action of psychedelics. The diversity of subjective effects elicited by different compounds has been attributed to the variables of "set" and "setting," to the binding affinities for other 5-HT receptor subtypes, and to the heterogeneity of transduction pathways initiated by conformational receptor states as they interact with different ligands ("functional selectivity"). Here we investigate the complementary (i.e., not mutually exclusive) possibility that such variety is also related to the binding affinity for a range of neurotransmitters and monoamine transporters including (but not limited to) 5-HT receptors. Building on two independent binding affinity datasets (compared to "in silico" estimates) in combination with natural language processing tools applied to a large repository of reports of psychedelic experiences (Erowid's Experience Vaults), we obtained preliminary evidence supporting that the similarity between the binding affinity profiles of psychoactive substituted phenethylamines and tryptamines is correlated with the semantic similarity of the associated reports. We also showed that the highest correlation was achieved by considering the combined binding affinity for the 5-HT, dopamine (DA), glutamate, muscarinic and opioid receptors and for the Ca+ channel. Applying dimensionality reduction techniques to the reports, we linked the compounds, receptors, transporters and the Ca+ channel to distinct fingerprints of the reported subjective effects. To the extent that the existing binding affinity data is based on a low number of displacement curves that requires further replication, our analysis produced preliminary evidence consistent with the involvement of different binding sites in the reported subjective effects elicited by psychedelics. Beyond the study of this particular class of drugs, we provide a methodological framework to explore the relationship between the binding affinity profiles and the reported subjective effects of other psychoactive compounds.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.rightsAcceso abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceFrontiers in Integrative Neuroscience. 2012, 12:54es
dc.subjectANALISIS SEMANTICOes
dc.subjectAFINIDADes
dc.subjectCONCIENCIAes
dc.subjectFENOMENOLOGIAes
dc.subjectSUSTANCIAS PSICOACTIVASes
dc.titleThe varieties of the psychedelic experience : a preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamineses
dc.typeArtículoes
dc.identifier.doi10.3389/fnint.2018.00054-
dc.identifier.pmid30467466-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Zamberlan, Federico. Universidad de Buenos Aires. Departamento de Física; Argentinaes
uca.affiliationFil: Zamberlan, Federico. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Sanz, Camila. Universidad de Buenos Aires. Departamento de Física; Argentinaes
uca.affiliationFil: Martínez Vivot, Rocío. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Martínez Vivot, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Martínez Vivot, Rocío. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Pallavicini, Carla. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Pallavicini, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Pallavicini, Carla. Fundación Para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentinaes
uca.affiliationFil: Erowid, Fire. Erowid Center; Estados Unidoses
uca.affiliationFil: Erowid, Earth. Erowid Center; Estados Unidoses
uca.affiliationFil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Departamento de Física; Argentinaes
uca.affiliationFil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentinaes
uca.affiliationFil: Tagliazucchi, Enzo. Institut du Cerveau et de la Moelle épinière; Franciaes
uca.versionpublishedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Cronofisiología-
crisitem.author.deptConsejo Nacional de Investigaciones Científicas y Técnicas-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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