Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/14226
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Zamberlan, Federico | es |
dc.contributor.author | Sanz, Camila | es |
dc.contributor.author | Martínez Vivot, Rocío | es |
dc.contributor.author | Pallavicini, Carla | es |
dc.contributor.author | Erowid, Fire | es |
dc.contributor.author | Erowid, Earth | es |
dc.contributor.author | Tagliazucchi, Enzo | es |
dc.date.accessioned | 2022-06-22T13:22:22Z | - |
dc.date.available | 2022-06-22T13:22:22Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Zamberlan, F. et al. The varieties of the psychedelic experience : a preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [en línea]. Frontiers in Integrative Neuroscience. 2012, 12:54 doi:10.3389/fnint.2018.00054 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14226 | es |
dc.identifier.issn | 1662-5145 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/14226 | - |
dc.description.abstract | Abstract: Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of the user ("set") and the surroundings ("setting"). The observation of cross-tolerance and a series of empirical studies in humans and animal models support agonism at the serotonin (5-HT)2A receptor as a common mechanism for the action of psychedelics. The diversity of subjective effects elicited by different compounds has been attributed to the variables of "set" and "setting," to the binding affinities for other 5-HT receptor subtypes, and to the heterogeneity of transduction pathways initiated by conformational receptor states as they interact with different ligands ("functional selectivity"). Here we investigate the complementary (i.e., not mutually exclusive) possibility that such variety is also related to the binding affinity for a range of neurotransmitters and monoamine transporters including (but not limited to) 5-HT receptors. Building on two independent binding affinity datasets (compared to "in silico" estimates) in combination with natural language processing tools applied to a large repository of reports of psychedelic experiences (Erowid's Experience Vaults), we obtained preliminary evidence supporting that the similarity between the binding affinity profiles of psychoactive substituted phenethylamines and tryptamines is correlated with the semantic similarity of the associated reports. We also showed that the highest correlation was achieved by considering the combined binding affinity for the 5-HT, dopamine (DA), glutamate, muscarinic and opioid receptors and for the Ca+ channel. Applying dimensionality reduction techniques to the reports, we linked the compounds, receptors, transporters and the Ca+ channel to distinct fingerprints of the reported subjective effects. To the extent that the existing binding affinity data is based on a low number of displacement curves that requires further replication, our analysis produced preliminary evidence consistent with the involvement of different binding sites in the reported subjective effects elicited by psychedelics. Beyond the study of this particular class of drugs, we provide a methodological framework to explore the relationship between the binding affinity profiles and the reported subjective effects of other psychoactive compounds. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Frontiers in Integrative Neuroscience. 2012, 12:54 | es |
dc.subject | ANALISIS SEMANTICO | es |
dc.subject | AFINIDAD | es |
dc.subject | CONCIENCIA | es |
dc.subject | FENOMENOLOGIA | es |
dc.subject | SUSTANCIAS PSICOACTIVAS | es |
dc.title | The varieties of the psychedelic experience : a preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3389/fnint.2018.00054 | - |
dc.identifier.pmid | 30467466 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Zamberlan, Federico. Universidad de Buenos Aires. Departamento de Física; Argentina | es |
uca.affiliation | Fil: Zamberlan, Federico. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Zamberlan, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Sanz, Camila. Universidad de Buenos Aires. Departamento de Física; Argentina | es |
uca.affiliation | Fil: Martínez Vivot, Rocío. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Martínez Vivot, Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Martínez Vivot, Rocío. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentina | es |
uca.affiliation | Fil: Pallavicini, Carla. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Pallavicini, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Pallavicini, Carla. Fundación Para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina | es |
uca.affiliation | Fil: Erowid, Fire. Erowid Center; Estados Unidos | es |
uca.affiliation | Fil: Erowid, Earth. Erowid Center; Estados Unidos | es |
uca.affiliation | Fil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Departamento de Física; Argentina | es |
uca.affiliation | Fil: Tagliazucchi, Enzo. Universidad de Buenos Aires. Instituto de Física de Buenos Aires; Argentina | es |
uca.affiliation | Fil: Tagliazucchi, Enzo. Institut du Cerveau et de la Moelle épinière; Francia | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Cronofisiología | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
varieties-psychedelic-experience.pdf | 4,76 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
98
comprobado en 28-mar-2024
Descarga(s)
28
comprobado en 28-mar-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons