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dc.contributor.authorAguilera Braico, Diegoes
dc.contributor.authorRoldán Deamicis, Agustinaes
dc.contributor.authorBrie, Belénes
dc.contributor.authorBalogh, Gabriela Andreaes
dc.date.accessioned2022-05-30T14:06:24Z-
dc.date.available2022-05-30T14:06:24Z-
dc.date.issued2017-
dc.identifier.citationAguilera Braico, D., et al. Comparative effect of Maitake Pro4x with chemotherapy breast cancer treatment [en línea]. Biology and Medicine. 201, 9(3) doi:10.4172/0974-8369.1000394 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14053es
dc.identifier.issn0974-8369-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/14053-
dc.description.abstractAbstract: Background: Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherOmics Internationales
dc.rightsAcceso abierto*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceBiology and Medicine. 201, 9(3)es
dc.subjectCANCER DE MAMAes
dc.subjectMaitake Pro4Xes
dc.subjectQUIMIOTERAPIAes
dc.titleComparative effect of Maitake Pro4x with chemotherapy breast cancer treatmentes
dc.typeArtículoes
dc.identifier.doi10.4172/0974-8369.1000394-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Aguilera Braico, Diego. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentinaes
uca.affiliationFil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Roldán Deamicis, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Brie, Belén. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Brie, Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas; Argentinaes
uca.affiliationFil: Balogh, Gabriela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.versionpublishedVersiones
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
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