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https://repositorio.uca.edu.ar/handle/123456789/14019
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Marullo, Rossella | es |
dc.contributor.author | Castro, Mónica | es |
dc.contributor.author | Yomtoubian, Shira | es |
dc.contributor.author | Calvo Vidal, M. Nieves | es |
dc.contributor.author | Revuelta, María Victoria | es |
dc.contributor.author | Krumsiek, Jan | es |
dc.contributor.author | Cho, Andrew | es |
dc.contributor.author | Cresta Morgado, Pablo | es |
dc.contributor.author | Yang, ShaoNing | es |
dc.contributor.author | Medina, Vanina Araceli | es |
dc.contributor.author | Roth, Berta M. | es |
dc.contributor.author | Bonomi, Marcelo | es |
dc.contributor.author | Keshari, Kayvan R. | es |
dc.contributor.author | Mittal, Vivek | es |
dc.contributor.author | Navigante, Alfredo | es |
dc.contributor.author | Cerchietti, Leandro | es |
dc.date.accessioned | 2022-05-24T15:19:06Z | - |
dc.date.available | 2022-05-24T15:19:06Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Marullo, R. et al. The metabolic adaptation evoked by arginine enhances the effect ofradiation in brain metastases [en línea]. Science Advances. 2021, 7 (45). doi: 10.1126/sciadv.abg1964. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/14019 | es |
dc.identifier.issn | 2375-2548 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/14019 | - |
dc.description.abstract | Abstract: Selected patients with brain metastases (BM) are candidates for radiotherapy. A lactatogenic metabolism, common in BM, has been associated with radioresistance. We demonstrated that BM express nitric oxide (NO) synthase 2 and that administration of its substrate L-arginine decreases tumor lactate in BM patients. In a placebo-controlled trial, we showed that administration of L-arginine before each fraction enhanced the effect of radiation, improving the control of BM. Studies in preclinical models demonstrated that L-arginine radiosensitization is a NO-mediated mechanism secondary to the metabolic adaptation induced in cancer cells. We showed that the decrease in tumor lactate was a consequence of reduced glycolysis that also impacted ATP and NAD+ levels. These effects were associated with NO-dependent inhibition of GAPDH and hyperactivation of PARP upon nitrosative DNA damage. These metabolic changes ultimately impaired the repair of DNA damage induced by radiation in cancer cells while greatly sparing tumor-infiltrating lymphocytes. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Association for the Advancement of Science | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Science Advances Vol.7, No.45, 2021 | es |
dc.subject | METASTASIS | es |
dc.subject | CEREBRO | es |
dc.subject | TUMORES | es |
dc.subject | ARGININA | es |
dc.subject | RADIACION | es |
dc.title | The metabolic adaptation evoked by arginine enhances the effect ofradiation in brain metastases | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1126/sciadv.abg1964 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Marullo, Rossella. Cornell University. Weill Cornell Medicine.Hematology and Oncology Division; Estados Unidos | es |
uca.affiliation | Fil: Castro, Mónica. Universidad de Buenos Aires. Instituto Oncológico Ángel Roffo. Unidad de Investigación Traslacional; Argentina | es |
uca.affiliation | Fil: Yomtoubian, Shira. Cornell University. Weill Cornell Medicine. Department of Cardiothoracic Surgery; Estados Unidos | es |
uca.affiliation | Fil: Yomtoubian, Shira. Cornell University. Weill Cornell Medicine. Department of Cell and Developmental Biology; Estados Unidos | es |
uca.affiliation | Fil: Calvo-Vidal, M. Nieves. Cornell University. Weill Cornell Medicine.Hematology and Oncology Division; Estados Unidos | es |
uca.affiliation | Fil: Revuelta, María Victoria. Cornell University. Weill Cornell Medicine.Hematology and Oncology Division; Estados Unidos | es |
uca.affiliation | Fil: Krumsiek, Jan. Weill Cornell Medicine. Institute for Computational Biomedicine. Department of Physiology and Biophysics; Estados Unidos | es |
uca.affiliation | Fil: Cho, Andrew. Universidad de Buenos Aires. Instituto Oncológico Ángel Roffo. Unidad de Investigación Traslacional; Argentina | es |
uca.affiliation | Fil: Cresta Morgado, Pablo. Universidad de Buenos Aires. Instituto Oncológico Ángel Roffo. Unidad de Investigación Traslacional; Argentina | es |
uca.affiliation | Fil: Yang, ShaoNing. Cornell University. Weill Cornell Medicine.Hematology and Oncology Division; Estados Unidos | es |
uca.affiliation | Fil: Medina, Vanina A. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Biología Tumoral e Inflamación; Argentina | es |
uca.affiliation | Fil: Roth, Berta M. Universidad de Buenos Aires. Instituto Oncológico Ángel Roffo. Departamento de Radiación e Imagenología; Argentina | es |
uca.affiliation | Fil: Medina, Vanina A. Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires; Argentina | es |
uca.affiliation | Fil: Medina, Vanina A. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Laboratorio de Radioisótopos; Argentina | es |
uca.affiliation | Fil: Bonomi, Marcelo. The Ohio State University. Hematology and Oncology Division; Estados Unidos | es |
uca.affiliation | Fil: Keshari, Kayvan R. Weill Cornell Graduate School. Department of Biochemistry and Structural Biology; Estados Unidos | es |
uca.affiliation | Fil: Keshari, Kayvan R. Memorial Sloan Kettering Cancer Center. Department of Radiology; Estados Unidos | es |
uca.affiliation | Fil: Keshari, Kayvan R. Memorial Sloan Kettering Cancer Center. Molecular Pharmacology Program; Estados Unidos | es |
uca.affiliation | Fil: Mittal, Vivek. Cornell University. Weill Cornell Medicine. Department of Cardiothoracic Surgery; Estados Unidos | es |
uca.affiliation | Fil: Mittal, Vivek. Cornell University. Weill Cornell Medicine. Department of Cell and Developmental Biology; Estados Unidos | es |
uca.affiliation | Fil: Navigante, Alfredo. Universidad de Buenos Aires. Instituto Oncológico Ángel Roffo. Unidad de Investigación Traslacional; Argentina | es |
uca.affiliation | Fil: Cerchietti, Leandro. Cornell University. Weill Cornell Medicine. Hematology and Oncology Division; Estados Unidos | es |
uca.version | publishedVersion | es |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Biología Tumoral e Inflamación | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-7767-0729 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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