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https://repositorio.uca.edu.ar/handle/123456789/12526
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Leite, Paulo Emilio Correa | es |
dc.contributor.author | Araujo Portes, Juliana de | es |
dc.contributor.author | Rodrigues Pereira, Mariana | es |
dc.contributor.author | Baldino Russo, Fabiele | es |
dc.contributor.author | Martins-Duarte, Erica S. | es |
dc.contributor.author | Almeida, Nathalia dos Santos | es |
dc.contributor.author | Attias, Marcia | es |
dc.contributor.author | Barrantes, Francisco José | es |
dc.contributor.author | Baleeiro Beltrão-Braga, Patricia Cristina | es |
dc.contributor.author | Souza, Wanderley de | es |
dc.date.accessioned | 2021-10-25T12:29:20Z | - |
dc.date.available | 2021-10-25T12:29:20Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Leite, P. E. Correa et al. Morphological and biochemical repercussions of Toxoplasma gondii infection in a 3D human brain neurospheres model [en línea]. Brain, Behavior, & Immunity - Health. 2021, 11 (100190). doi: https://doi.org/10.1016/j.bbih.2020.100190. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/12526 | es |
dc.identifier.issn | 2666-3546 (online) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/12526 | - |
dc.description.abstract | Abstract: Background: Toxoplasmosis is caused by the parasite Toxoplasma gondii that can infect the central nervous system (CNS), promoting neuroinflammation, neuronal loss, neurotransmitter imbalance and behavioral alterations. T. gondii infection is also related to neuropsychiatric disorders such as schizophrenia. The pathogenicity and inflammatory response in rodents are different to the case of humans, compromising the correlation between the behavioral alterations and physiological modifications observed in the disease. In the present work we used BrainSpheres, a 3D CNS model derived from human pluripotent stem cells (iPSC), to investigate the morphological and biochemical repercussions of T. gondii infection in human neural cells. Methods: We evaluated T. gondii ME49 strain proliferation and cyst formation in both 2D cultured human neural cells and BrainSpheres. Aspects of cell morphology, ultrastructure, viability, gene expression of neural phenotype markers, as well as secretion of inflammatory mediators were evaluated for 2 and 4 weeks post infection in BrainSpheres. Results: T. gondii can infect BrainSpheres, proliferating and inducing cysts formation, neural cell death, alteration in neural gene expression and triggering the release of several inflammatory mediators. Conclusions: BrainSpheres reproduce many aspects of T. gondii infection in human CNS, constituting a useful model to study the neurotoxicity and neuroinflammation mediated by the parasite. In addition, these data could be important for future studies aiming at better understanding possible correlations between psychiatric disorders and human CNS infection with T. gondii. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Brain, Behavior, & Immunity - Health Vol.11, 100190, 2021 | es |
dc.subject | TOXOPLASMA GONDII | es |
dc.subject | TRASTORNOS NEUROPSIQUIATRICOS | es |
dc.subject | INFLAMACION | es |
dc.subject | CEREBRO | es |
dc.title | Morphological and biochemical repercussions of Toxoplasma gondii infection in a 3D human brain neurospheres model | es |
dc.type | Artículo | es |
dc.identifier.doi | https://doi.org/10.1016/j.bbih.2020.100190 | - |
dc.identifier.pmid | 34589727 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Leite, Paulo Emilio Correa. Institute of Biophysics Carlos Chagas Filho; Brasil | es |
uca.affiliation | Fil: Leite, Paulo Emilio Correa. National Center for Structural Biology and Bioimaging; Brasil | es |
uca.affiliation | Fil: Leite, Paulo Emilio Correa. Federal University of Rio de Janeiro; Brasil | es |
uca.affiliation | Fil: Leite, Paulo Emilio Correa. Directory of Metrology Applied to Life Sciences; Brasil | es |
uca.affiliation | Fil: Leite, Paulo Emilio Correa. National Institute of Metrology Quality and Technology; Brasil | es |
uca.affiliation | Fil: Araujo Portes, Juliana de. Institute of Biophysics Carlos Chagas Filho; Brasil | es |
uca.affiliation | Fil: Araujo Portes, Juliana de. National Center for Structural Biology and Bioimaging; Brasil | es |
uca.affiliation | Fil: Araujo Portes, Juliana de. Federal University of Rio de Janeiro; Brasil | es |
uca.affiliation | Fil: Rodrigues Pereira, Mariana. Fluminense Federal University. Biology Institute; Brasil | es |
uca.affiliation | Fil: Baldino Russo, Fabiele. University of Sao Paulo. Institute of Biomedical Science,; Brasil | es |
uca.affiliation | Fil: Baldino Russo, Fabiele. Laboratory of Disease Modeling, Department of Microbiology; Brasil | es |
uca.affiliation | Fil: Martins-Duarte, Erica S. Institute of Biophysics Carlos Chagas Filho; Brasil | es |
uca.affiliation | Fil: Martins-Duarte, Erica S. National Center for Structural Biology and Bioimaging; Brasil | es |
uca.affiliation | Fil: Martins-Duarte, Erica S. Federal University of Rio de Janeiro; Brasil | es |
uca.affiliation | Fil: Martins-Duarte, Erica S. Federal University of Minas Gerais. Department of Parasitology; Brasil | es |
uca.affiliation | Fil: Almeida, Nathalia dos Santos. Laboratory of Disease Modeling, Department of Microbiology; Brasil | es |
uca.affiliation | Fil: Almeida, Nathalia dos Santos. University of Sao Paulo. Institute of Biomedical Science; Brasil | es |
uca.affiliation | Fil: Attias, Marcia. Institute of Biophysics Carlos Chagas Filho; Brasil | es |
uca.affiliation | Fil: Attias, Marcia. National Center for Structural Biology and Bioimaging; Brasil | es |
uca.affiliation | Fil: Attias, Marcia. Federal University of Rio de Janeiro; Brasil | es |
uca.affiliation | Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco José. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina | es |
uca.affiliation | Fil: Baleeiro Beltrão-Braga, Patricia Cristina. Laboratory of Disease Modeling, Department of Microbiology; Brasil | es |
uca.affiliation | Fil: Baleeiro Beltrão-Braga, Patricia Cristina. University of Sao Paulo. Institute of Biomedical Science; Brasil | es |
uca.affiliation | Fil: Baleeiro Beltrão-Braga, Patricia Cristina. Scientific Platform Pasteur-USP | es |
uca.affiliation | Fil: Souza, Wanderley de. Institute of Biophysics Carlos Chagas Filho; Brasil | es |
uca.affiliation | Fil: Souza, Wanderley de. National Center for Structural Biology and Bioimaging; Brasil | es |
uca.affiliation | Fil: Souza, Wanderley de. Federal University of Rio de Janeiro; Brasil | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-4745-681X | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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