Please use this identifier to cite or link to this item:
https://repositorio.uca.edu.ar/handle/123456789/12481
DC Field | Value | Language |
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dc.contributor.author | Palumbo, María Laura | es |
dc.contributor.author | Moroni, Alejandro David | es |
dc.contributor.author | Quiroga, Sofia | es |
dc.contributor.author | Castro, María Micaela | es |
dc.contributor.author | Burgueño, Adriana Laura | es |
dc.contributor.author | Genaro, Ana María | es |
dc.date.accessioned | 2021-10-19T11:35:54Z | - |
dc.date.available | 2021-10-19T11:35:54Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Palumbo, M. L., et al. Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders [en línea]. Pharmacol Res Perspect. 2021, 9 (5) doi:10.1002/prp2.795. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/12481 | es |
dc.identifier.issn | 2052-1707 (en línea) | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/12481 | - |
dc.description.abstract | Abstract: Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. The incidence of these diseases is increasing and has a great impact due to their high morbidity and mortality. Unfortunately, current therapeutic strategies only temporarily improve the patients’ quality of life but are insufficient for completely alleviating the symptoms. An interaction between the immune system and the central nervous system (CNS) is widely associated with neuronal damage in NDD. Usually, immune cell infiltration has been identified with inflammation and is considered harmful to the injured CNS. However, the immune system has a crucial role in the protection and regeneration of the injured CNS. Nowadays, there is a consensus that deregulation of immune homeostasis may represent one of the key initial steps in NDD. Dr. Michal Schwartz originally conceived the concept of “protective autoimmunity” (PA) as a well-controlled peripheral inflammatory reaction after injury, essential for neuroprotection and regeneration. Several studies suggested that immunizing with a weaker version of the neural self-antigen would generate PA without degenerative autoimmunity. The development of CNS-related peptides with immunomodulatory neuroprotective effect led to important research to evaluate their use in chronic and acute NDD. In this review, we refer to the role of PA and the potential applications of active immunization as a therapeutic option for NDD treatment. In particular, we focus on the experimental and clinical promissory findings for CNS-related peptides with beneficial immunomodulatory effects. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | John Wiley & Sons Ltd British Pharmacological Society | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Pharmacol Res Perspect. 2021, 9 (5) | es |
dc.subject | NEURODEGENERACION | es |
dc.subject | SISTEMA NERVIOSO CENTRAL | es |
dc.subject | ENFERMEDADES NEURODEGENERATIVAS | es |
dc.subject | SISTEMA INMUNOLOGICO | es |
dc.subject | NEUROPROTECCION | es |
dc.title | Immunomodulation induced by central nervous system-related peptides as a therapeutic strategy for neurodegenerative disorders | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1002/prp2.795 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Palumbo, María Laura. Universidad Nacional de San Antonio de Areco. Universidad Nacional del Noroeste de la Provincia.de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Moroni, Alejandro David. Universidad Nacional de San Antonio de Areco. Universidad Nacional del Noroeste de la Provincia.de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Quiroga, Sofia. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Castro, María Micaela. Universidad Nacional de San Antonio de Areco. Universidad Nacional del Noroeste de la Provincia.de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Burgueño, Adriana Laura. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Genaro, Ana María. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Psiconeuroendocrinoinmunología | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Psiconeuroendocrinoinmunología | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Psiconeuroendocrinoinmunología | - |
crisitem.author.orcid | 0000-0003-0027-3503 | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
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