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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Pérez Lloret, Santiago | es |
dc.contributor.author | Cardinali, Daniel Pedro | es |
dc.date.accessioned | 2021-06-14T16:58:00Z | - |
dc.date.available | 2021-06-14T16:58:00Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Pérez Lloret, S., Cardinali, D. P. Melatonin as a chronobiotic and cytoprotective agent in Parkinson’s disease [en línea]. Frontiers in pharmacology. 2021, 12 (650597). doi:10.3389/fphar.2021.650597. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/11620 | es |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/11620 | - |
dc.description.abstract | Abstract: This article discusses the role that melatonin may have in the prevention and treatment of Parkinson’s disease (PD). In parkinsonian patients circulating melatonin levels are consistently disrupted and the potential therapeutic value of melatonin on sleep disorders in PD was examined in a limited number of clinical studies using 2–5mg/ day melatonin at bedtime. The low levels of melatonin MT1 and MT2 receptor density in substantia nigra and amygdala found in PD patients supported the hypothesis that the altered sleep/wake cycle seen in PD could be due to a disrupted melatonergic system. Motor symptomatology is seen in PD patients when about 75%of the dopaminergic cells in the substantia nigra pars compacta region degenerate. Nevertheless, symptoms like rapid eye movement (REM) sleep behavior disorder (RBD), hyposmia or depression may precede the onset of motor symptoms in PD for years and are index of worse prognosis. Indeed, RBD patients may evolve to an α-synucleinopathy within 10 years of RBD onset. Daily bedtime administration of 3–12 mg of melatonin has been demonstrated effective in RDB treatment and may halt neurodegeneration to PD. In studies on animal models of PD melatonin was effective to curtail symptomatology in doses that allometrically projected to humans were in the 40–100 mg/day range, rarely employed clinically. Therefore, double-blind, placebo-controlled clinical studies are urgently needed in this respect. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Frontiers in pharmacology Vol.12, Art.650597, 2021 | es |
dc.subject | MELATONINA | es |
dc.subject | ENFERMEDAD DE PARKINSON | es |
dc.subject | ENVEJECIMIENTO | es |
dc.subject | NEURODEGENERACION | es |
dc.subject | ENFERMEDADES NEURODEGENERATIVAS | es |
dc.subject | TRATAMIENTO MEDICO | es |
dc.title | Melatonin as a chronobiotic and cytoprotective agent in Parkinson’s disease | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3389/fphar.2021.650597 | - |
dc.identifier.pmid | 33935759 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Pérez Lloret, Santiago. Universidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud; Argentina | es |
uca.affiliation | Fil: Pérez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.affiliation | Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina | es |
uca.affiliation | Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas; Argentina | es |
uca.version | publishedVersion | es |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Consejo Nacional de Investigaciones Científicas y Técnicas | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0001-9069-6512 | - |
crisitem.author.orcid | 0000-0002-0813-9088 | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
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