Por favor, use este identificador para citar o enlazar este ítem:
https://repositorio.uca.edu.ar/handle/123456789/10847
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Borroni, María Virginia | es |
dc.contributor.author | Kamerbeek, Constanza B. | es |
dc.contributor.author | Pediconi, María F. | es |
dc.contributor.author | Barrantes, Francisco José | es |
dc.date.accessioned | 2020-11-04T00:01:26Z | - |
dc.date.available | 2020-11-04T00:01:26Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Borroni, M. V., Kamerbeek; C. B., Pediconi, M. F., Barrantes, F. J. Lovastatin differentially regulates α7 and α4 neuronal nicotinic acetylcholine receptor levels in rat hippocampal neurons [en línea]. Molecules. 2020, 25 (4838). Disponible en: https://repositorio.uca.edu.ar/handle/123456789/10847 | es |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://repositorio.uca.edu.ar/handle/123456789/10847 | - |
dc.description.abstract | Abstract: Neuronal 7 and 4 2 are the predominant nicotinic acetylcholine receptor (nAChR) subtypes found in the brain, particularly in the hippocampus. The e ects of lovastatin, an inhibitor of cholesterol biosynthesis, on these two nAChRs endogenously expressed in rat hippocampal neuronal cells were evaluated in the 0.01–1 M range. Chronic (14 days) lovastatin treatment augmented cell-surface levels of 7 and 4 nAChRs, as measured by fluorescence microscopy and radioactive ligand binding assays. This was accompanied in both cases by an increase in total protein receptor levels as determined byWestern blots. At low lovastatin concentrations (10–100 nM), the increase in 4 nAChR in neurites was higher than in neuronal cell somata; the opposite occurred at higher (0.5–1 M) lovastatin concentrations. In contrast, neurite 7 nAChRs raised more than somatic 7 nAChRs at all lovastatin concentrations tested. These results indicate that cholesterol levels homeostatically regulate 7 and 4 nAChR levels in a di erential manner through mechanisms that depend on statin concentration and receptor localization. The neuroprotective pleomorphic e ects of statins may act by reestablishing the homeostatic equilibrium. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights | Acceso abierto | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Molecules. 2020, 25 (4838) | es |
dc.subject | MEDICINA | es |
dc.subject | COLESTEROL | es |
dc.subject | RECEPTORES | es |
dc.subject | ENFERMEDAD DE ALZHEIMER | es |
dc.subject | NEURONAS | es |
dc.subject | HIPOCAMPO | es |
dc.title | Lovastatin differentially regulates α7 and α4 neuronal nicotinic acetylcholine receptor levels in rat hippocampal neurons | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3390/molecules25204838 | - |
uca.disciplina | MEDICINA | es |
uca.issnrd | 1 | es |
uca.affiliation | Fil: Borroni, María Virginia. Universidad de Buenos Aires. Facultad de Arquitectura, Diseño y Urbanismo. Instituto de Tecnología en Polímeros y Nanotecnología; Argentina | es |
uca.affiliation | Fil: Borroni, María Virginia. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina | es |
uca.affiliation | Fil: Kamerbeek, Constanza B. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina | es |
uca.affiliation | Fil: Pediconi, María F. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco José. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurobiología Molecular; Argentina | es |
uca.affiliation | Fil: Barrantes, Francisco José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | es |
uca.version | publishedVersion | es |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.dept | Laboratorio de Neurobiología Molecular | - |
crisitem.author.dept | Facultad de Ciencias Médicas | - |
crisitem.author.orcid | 0000-0002-4745-681X | - |
crisitem.author.parentorg | Facultad de Ciencias Médicas | - |
crisitem.author.parentorg | Instituto de Investigaciones Biomédicas - BIOMED | - |
crisitem.author.parentorg | Pontificia Universidad Católica Argentina | - |
Aparece en las colecciones: | Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
lovastatin-iferentially-regulates.pdf | 4,1 MB | Adobe PDF | Visualizar/Abrir |
Visualizaciones de página(s)
124
comprobado en 27-abr-2024
Descarga(s)
116
comprobado en 27-abr-2024
Google ScholarTM
Consultar
Altmetric
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons