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dc.contributor.authorTerroba-Chambi, Cinthiaes
dc.contributor.authorBruno, Verónicaes
dc.contributor.authorVigo, Daniel Eduardoes
dc.contributor.authorMerello, Marceloes
dc.date.accessioned2020-07-08T23:43:27Z-
dc.date.available2020-07-08T23:43:27Z-
dc.date.issued2020-
dc.identifier.citationTerroba-Chambi, C., et al. Heart rate variability and falls in Huntington’s disease [en línea]. Postprint de artículo publicado en Clinical Autonomic Research. 2020. doi:10.1007/s10286-020-00669-2. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/1035es
dc.identifier.issn0959-9851 (impreso)-
dc.identifier.issn1619-156 (online)-
dc.identifier.urihttps://repositorio.uca.edu.ar/handle/123456789/10351-
dc.description.abstractAbstract: Purpose: Huntington's disease (HD) patients have a high prevalence of falls. Autonomic nervous system dysfunction has been reported from the early stages of the disease. There is no evidence analyzing the relationship between heart rate variability (HRV) and falls in this population. This research aimed to evaluate the relationship between HRV and falls in HD. Methods: HD patients enrolled in a prospective study of Fear of Falling and falls were assessed using short-term HRV analyses and blood pressure measures in resting and standing states. Time-frequency domains and nonlinear parameters were calculated. Data regarding falls, the risk of falling (RoF) and disease-specific scales were collected at baseline and six-month follow-up. Results: Twenty HD patients were recruited. 35% of HD patients reported at least one fall (single fallers) and, 65% reported two or more falls (recurrent fallers) in the previous 12-months. At baseline, recurrent fallers had lower RMSSD-resting (root-mean-square-of-the-RR), higher LF/HF ratio (low/high frequency) in both states, and higher DFA-α1 parameter (short-term-detrended-fluctuation-analyses) in both states. This association was similar at a six-month follow-up for recurrent fallers showing lower RMSSD-resting and higher LF/HF-standing ratio than single fallers. Significant correlations were found between the number of falls, RMSSD-resting, and LF/HF-standing ratio. No differences were found between recurrent and single fallers for any blood pressure measures. Conclusions: The observed HRV pattern is consistent with a higher sympathetic prevalence associated with a higher RoF. Reduced parasympathetic HRV values predict being a recurrent faller at six-months of follow-up, independently of orthostatic phenomena in this population.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherSpringer Naturees
dc.rightsAcceso abierto. 12 meses de embargo*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourcePostprint de artículo publicado en Clinical Autonomic Research. 2020es
dc.subjectENFERMEDAD DE HUNTINGTONes
dc.subjectSISTEMA NERVIOSO AUTONOMOes
dc.subjectFRECUENCIA CARDIACAes
dc.subjectTRASTORNOS DEL MOVIMIENTOes
dc.titleHeart rate variability and falls in Huntington’s diseasees
dc.typeArtículoes
dc.identifier.doi10.1007/s10286-020-00669-2-
dc.identifier.pmid32026136-
uca.disciplinaMEDICINAes
uca.issnrd1es
uca.affiliationFil: Terroba-Chambi, Cinthia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto Raul Carrea. Unidad de Trastornos del Movimiento; Argentinaes
uca.affiliationFil: Terroba-Chambi, Cinthia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Bruno, Veronica. University of Calgary. Department of Neuroscience; Canadáes
uca.affiliationFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina. Facultad de Ciencias Médicas. Instituto de Investigaciones Biomédicas. Laboratorio de Neurociencia Aplicada y Espacial; Argentinaes
uca.affiliationFil: Vigo, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.affiliationFil: Vigo, Daniel Eduardo. Katholieke Universiteit Leuven. Faculty of Psychology and Educational Sciences; Bélgicaes
uca.affiliationFil: Merello, Marcelo. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia. Instituto Raul Carrea. Unidad de Trastornos del Movimiento; Argentinaes
uca.affiliationFil: Merello, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinaes
uca.versionacceptedVersiones
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
crisitem.author.deptInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.deptLaboratorio de Cronofisiología-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.deptFacultad de Ciencias Médicas-
crisitem.author.orcid0000-0003-2291-245X-
crisitem.author.parentorgFacultad de Ciencias Médicas-
crisitem.author.parentorgInstituto de Investigaciones Biomédicas - BIOMED-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
crisitem.author.parentorgPontificia Universidad Católica Argentina-
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