https://repositorio.uca.edu.ar/handle/123456789/657 2026-07-05T16:13:23Z https://repositorio.uca.edu.ar/handle/123456789/22063 Título: Protecting young minds: insights on pre-adolescents’ mental health from a school-based study in Argentina Autor: Kaliman, Perla; Álvarez-López, María Jesús; Lisenberg, Marina; Acosta, María Agustina; Simkin, Denise Agostina; Martínez Vivot, Rocío Resumen: Background: Childhood and adolescent mental health is in crisis globally, emphasizing the need for early detection and prevention strategies. Children from marginalized neighborhoods are particularly vulnerable, yet data on their psychological well-being is still limited in Argentina. Objectives: We aimed to explore mental health characteristics of vulnerable school children and assess the feasibility of a psychological well-being promoting program. Participants and setting: This study was conducted in a primary school in a disadvantaged neighborhood of Buenos Aires, Argentina, involving 35 children aged 11. Methods: Participants completed validated Spanish versions of scales assessing perceived stress (PSS-14), PTSD symptoms (CPSS), empathy, mindfulness (MAAS-A), and self-compassion (SCS-SF). Sex differences and correlations between scales were explored. Findings: Significant sex disparities were found in perceived stress, with girls reporting higher scores (p = 0.002). PTSD symptoms were alarmingly high, with 74 % of participants exceeding the clinical cut-off of 16 (girls: mean = 27.48, SD = 9.45; boys: mean = 17.36, SD = 12.76; p = 0.017). Boys scored higher in self-compassion (p = 0.003). Positive correlations were found between stress and PTSD symptoms (r = 0.597, p < 0.001) and between mindfulness and self-compassion (r = 0.439, p = 0.008). Both dispositional mindfulness and self-compassion negatively correlated with perceived stress (r = − 0.526, p = 0.001; r = − 0.595, p < 0.001, respectively) and PTSD symptoms (r = − 0.616, p < 0.001; r = − 0.561, p < 0.001, respectively). Conclusion: Our study highlights the significant vulnerability of this population, emphasizing the urgency for early detection and gender- and trauma-sensitive prevention efforts. Notably, our findings suggest that mindfulness and self-compassion training may be key protective components within mental health-promoting interventions for preadolescents. 2025-01-01T00:00:00Z https://repositorio.uca.edu.ar/handle/123456789/22034 Título: Manual de gestión de sueño y riesgos asociados a la fatiga para las fuerzas armadas Autor: Folgueira, Agustín Leandro; Mul Fedele, Malena Lis; Vigo, Daniel Eduardo Resumen: El sueño es una función vital que ocupa un tercio de la vida humana y permite afrontar las exigencias diarias. Sin embargo, el trabajo en jornadas extendidas, nocturnas o rotativas en tiempos de paz y con el ritmo implacable de los conflictos modernos exige que el personal militar pueda actuar bajo un estado de privación de sueño. Esta situación afecta el rendimiento de manera tan significativa que representa un riesgo crítico en tiempos de paz y puede convertirse en una ventaja estratégica para el enemigo en tiempos de guerra. Sobre estos principios surge este libro, resultado de un proceso de aprendizaje continuo y de la exploración de soluciones a los desafíos del sueño en el ámbito militar argentino. Esta obra busca compartir parte del camino recorrido. 2025-01-01T00:00:00Z https://repositorio.uca.edu.ar/handle/123456789/22031 Título: Hyperthyroidism-induced lymphoid cell activation in the lymph nodes and spleen of BALB/c mice Autor: Rocco, María Belén; Requena D'Alessio, Clara; Sánchez, Valeria Giselle; Romeo, Horacio Eduardo See "Romeo, Horacio"; Barreiro Arcos, María Laura Resumen: Introduction: Hyperthyroidism is known to affect various physiological systems, including the immune system. Thyroid hormones (THs) play a crucial role in regulating immune function, and alterations in THs levels can lead to immune dysregulation. 2025-01-01T00:00:00Z https://repositorio.uca.edu.ar/handle/123456789/22029 Título: Histamine H3 receptor: an emerging target for cancer therapy? Autor: Lauretta, Paolo; Martínez Vivot, Rocío; Velazco, Águeda; Medina, Vanina Alejandra Resumen: Achieving better clinical outcomes in cancer research requires a deeper understanding of tumoral biology and the application of this knowledge within a clinic setting. The aim of this review is to briefly summarize the current knowledge on H3R molecular pharmacology, the clinical use of H3R antagonists, and the most recent findings reporting H3R role in cancer biology. We will discuss in detail the current landscape and clinical perspectives of the modulation of this H3R on cancer progression and treatment. We propose H3R as a promising molecular target for cancer drug repurposing and development. 2025-01-01T00:00:00Z