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Protecting young minds: insights on pre-adolescents’ mental health from a school-based study in Argentina

2026-07-03T07:01:21Z

Título: Protecting young minds: insights on pre-adolescents’ mental health from a school-based study in Argentina Autor: Kaliman, Perla; Álvarez-López, María Jesús; Lisenberg, Marina; Acosta, María Agustina; Simkin, Denise Agostina; Martínez Vivot, Rocío Resumen: Background: Childhood and adolescent mental health is in crisis globally, emphasizing the need for early detection and prevention strategies. Children from marginalized neighborhoods are particularly vulnerable, yet data on their psychological well-being is still limited in Argentina. Objectives: We aimed to explore mental health characteristics of vulnerable school children and assess the feasibility of a psychological well-being promoting program. Participants and setting: This study was conducted in a primary school in a disadvantaged neighborhood of Buenos Aires, Argentina, involving 35 children aged 11. Methods: Participants completed validated Spanish versions of scales assessing perceived stress (PSS-14), PTSD symptoms (CPSS), empathy, mindfulness (MAAS-A), and self-compassion (SCS-SF). Sex differences and correlations between scales were explored. Findings: Significant sex disparities were found in perceived stress, with girls reporting higher scores (p = 0.002). PTSD symptoms were alarmingly high, with 74 % of participants exceeding the clinical cut-off of 16 (girls: mean = 27.48, SD = 9.45; boys: mean = 17.36, SD = 12.76; p = 0.017). Boys scored higher in self-compassion (p = 0.003). Positive correlations were found between stress and PTSD symptoms (r = 0.597, p < 0.001) and between mindfulness and self-compassion (r = 0.439, p = 0.008). Both dispositional mindfulness and self-compassion negatively correlated with perceived stress (r = − 0.526, p = 0.001; r = − 0.595, p < 0.001, respectively) and PTSD symptoms (r = − 0.616, p < 0.001; r = − 0.561, p < 0.001, respectively). Conclusion: Our study highlights the significant vulnerability of this population, emphasizing the urgency for early detection and gender- and trauma-sensitive prevention efforts. Notably, our findings suggest that mindfulness and self-compassion training may be key protective components within mental health-promoting interventions for preadolescents.

Hyperthyroidism-induced lymphoid cell activation in the lymph nodes and spleen of BALB/c mice

2026-07-02T07:01:24Z

Título: Hyperthyroidism-induced lymphoid cell activation in the lymph nodes and spleen of BALB/c mice Autor: Rocco, María Belén; Requena D'Alessio, Clara; Sánchez, Valeria Giselle; Romeo, Horacio Eduardo See "Romeo, Horacio"; Barreiro Arcos, María Laura Resumen: Introduction: Hyperthyroidism is known to affect various physiological systems, including the immune system. Thyroid hormones (THs) play a crucial role in regulating immune function, and alterations in THs levels can lead to immune dysregulation.

Histamine H3 receptor: an emerging target for cancer therapy?

2026-07-02T07:01:20Z

Título: Histamine H3 receptor: an emerging target for cancer therapy? Autor: Lauretta, Paolo; Martínez Vivot, Rocío; Velazco, Águeda; Medina, Vanina Alejandra Resumen: Achieving better clinical outcomes in cancer research requires a deeper understanding of tumoral biology and the application of this knowledge within a clinic setting. The aim of this review is to briefly summarize the current knowledge on H3R molecular pharmacology, the clinical use of H3R antagonists, and the most recent findings reporting H3R role in cancer biology. We will discuss in detail the current landscape and clinical perspectives of the modulation of this H3R on cancer progression and treatment. We propose H3R as a promising molecular target for cancer drug repurposing and development.

Guidelines for diet-induced models of cardiometabolic syndrome

2026-07-02T07:01:39Z

Título: Guidelines for diet-induced models of cardiometabolic syndrome Autor: Sveeggen, Timothy M.; Bagher, Pooneh; Toba, Hiroe; Lindsey, Merry L.; Ritchie, Rebecca H.; Miksztowicz, Verónica J.; González, Germán E. Resumen: Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension, that collectively increase the risk of cardiovascular disease and type 2 diabetes. Animal models are widely used to study CMS, with diet-induced models being the most physiologically relevant. A lack of reporting standards and variability in dietary composition, feeding duration, and macronutrient content across studies hinder reproducibility assessment and translational impact evaluation. We provide standardized guidelines for the consideration, preparation, and use of diets in experimental models of CMS. Advantages and limitations of different diet-induced models are compared with genetic and pharmacological approaches, emphasizing replicability to human metabolic dysregulation. Key components include macronutrient composition, fat source selection, feeding duration, strain susceptibility, and sex differences. In addition, we outline husbandry practices, including environmental factors, bedding material, and enrichment conditions, which can affect metabolic outcomes. Standardization is essential for enhancing experimental reproducibility and facilitating cross-study comparisons. These guidelines serve as a framework for researchers to optimize dietary interventions in CMS models, improving the predictive value of preclinical findings for translational applications to aid in the development of targeted therapeutic strategies.